Why You’re Reacting to More Foods Than Ever

If you feel like your body is suddenly reacting to more and more foods, you’re not alone. Maybe you could eat dairy, eggs, or gluten without issue before, but now even a small bite triggers bloating, fatigue, rashes, or brain fog. It can be confusing and frustrating. You might even start to wonder: “Am I allergic to everything?”

We often see this pattern, and one major contributor is something called leaky gut, paired with an overloaded immune system. Let’s break it down together so you can understand what might be happening inside your body and, more importantly, what you can do about it.

What Is Leaky Gut?

Your gut is home to a long tube called the intestinal lining. Think of it like a finely woven net that decides what gets into your bloodstream and what stays out. Normally, this lining lets in nutrients from your food but keeps out things like undigested food particles, bacteria, and toxins.

When that net becomes damaged or "leaky," larger and unwanted particles can pass through. This is known as intestinal permeability, or more commonly, leaky gut. When things that aren’t supposed to enter your bloodstream sneak in, your immune system sees them as invaders and reacts.

Over time, these immune reactions can start happening every time you eat certain foods. Your body becomes more reactive, and you might find yourself unable to tolerate foods you once loved.

How the Immune System Gets Overwhelmed

Your immune system is like your body's personal security team. Its job is to protect you from harm, including viruses, bacteria, and toxins. But when it gets overwhelmed, whether from stress, poor sleep, environmental toxins, infections, or a leaky gut, it starts to lose its ability to tell friend from foe.

Instead of calming down after doing its job, your immune system may stay on high alert. And in this heightened state, it might start attacking harmless things, like proteins in your food. This is one reason food sensitivities seem to grow over time: your immune system is essentially tired and overworked.

Why More Foods? Why Now?

So why does it feel like you're reacting to more foods than ever?

Accumulated Stress on the Gut: Over time, things like antibiotics, processed foods, alcohol, chronic stress, and even medications can wear down your gut lining.
Cross-Reactivity: Sometimes your immune system thinks different foods are similar and starts reacting to those, too. For example, if you react to gluten, you might also start reacting to oats or dairy due to similar protein structures.
Poor Gut Health: Imbalanced gut bacteria (called dysbiosis) can increase inflammation and weaken the gut lining.
Mast Cell Activation: Certain cells in your body that release histamine can become overly sensitive, making you react to foods, smells, and even temperature changes.
Too Many Toxins: Environmental toxins, mold, and heavy metals can burden your immune system, making it more reactive.

Functional Testing: Understanding What Your Body Needs

One of the most helpful tools to determine what is going on in your body is advanced lab testing. These tests go beyond standard blood work to help identify hidden imbalances that may be contributing to food reactivity.

1. Comprehensive Stool Analysis

This test evaluates your gut microbiome, inflammation markers, digestion, and potential pathogens. It can reveal imbalances in bacteria, yeast overgrowth, and whether your gut lining is inflamed or leaking.

2. Food Sensitivity Testing

Some practitioners may use IgG or IgA-based food sensitivity tests to see how your immune system is responding to different foods. While these tests aren’t perfect, they can offer useful clues when interpreted with your symptoms and history.

3. Intestinal Permeability Testing

Specific tests can measure how "leaky" your gut is by assessing the movement of molecules through your intestinal lining. This can help determine if your gut barrier needs repair.

4. Micronutrient Testing

Nutrient deficiencies, such as low levels of zinc, vitamin D, or glutamine, can impact gut health and immune function. Testing can guide more targeted supplementation.

5. Inflammatory and Immune Panels

Markers like CRP (C-reactive protein), cytokines, or immune cell balances can provide insight into how inflamed or overloaded your immune system might be.

If you’re reacting to more foods than ever, it doesn’t mean your body is failing. In fact, it’s a sign your body is doing exactly what it was designed to do: protect you.

Understanding the connection between your gut and your immune system gives you the power to take steps toward healing. With the right support, a tailored plan, and some patience, it is possible to calm your system and regain food freedom.

References

Albert-Bayo, M., et al. (2019). Intestinal Mucosal Mast Cells: Key Modulators of Barrier Function. Frontiers in Immunology.
Valitutti, F., et al. (2025). Intestinal permeability, food antigens and the microbiome. Frontiers in Allergy.
Poto, R., et al. (2023). The Role of Gut Microbiota and Leaky Gut in Food Allergy. Nutrients.
Zhang, L., et al. (2016). Mast Cells and Irritable Bowel Syndrome: From the Bench. Journal of Neurogastroenterology and Motility.
Ishihara, N., et al. (2022). Spi-B alleviates food allergy by securing mucosal barrier. Frontiers in Allergy.
Andreou, E., et al. (2025). Boosting Immunity Through Nutrition and Gut Health. Nutrients.